![]() ![]() Localized LAP is more common and it has been reported to affect nearly 75 percent of patients presenting with LAP, whereas 25 percent of those patients had generalized LAP. Lymphadenopathy is considered to be localized if only one group of LN is involved, limited if 2-3 groups of LN are involved and generalized if more than three noncontiguous groups are involved. Fortunately, the majority of patients presenting with peripheral LAP have easily identifiable causes that are benign or self-limiting. Lymphadenopathy can be defined as LNs that are abnormal in size, consistency or number. Studies have shown that as many as 56% of patients examined for other reasons may be found to have lymphadenopathy (LAP). The peripheral groups are those readily palpable by clinical examination, and routinely looked for, but only those in the submandibular, axillary or inguinal regions may normally be palpable in healthy individuals. The body has approximately 600 LNs, and their locations are scattered around ports of entry as well as major vessels. Lymph nodes (LNs) are group of specialized cells that represent a division of the defense system in the human body. In this review article, we provide evidence-based clinical evaluation of LAP, guided by the probability of the underlying disease to assist clinicians in establishing the proper cause and hence offer appropriate management. However, a methodological approach to LAP can disclose the accurate diagnosis with minimal discomfort to the patient and in a short time. Lymph node aspiration or biopsy for histopathological evaluation may not reveal the diagnosis due to several factors. The enlargement of a lymph node, due to primary disease or secondary cause, is of concern to both patients and clinicians, particularly, if the underlying pathology is a malignant disease. Lymphadenopathy (LAP) is a common clinical finding that may be localized, limited or generalized.
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